Explain why the cell is more likely to employ a two-component system with a transmembrane sensor kinase (with sensor domain exposed to the periplasm) than a cytoplasmic one-component system to sense the antibiotic and induce expression of the efflux transporter.

You are interested in mechanisms of antibiotic resistance for your microbe of interest. The antibiot Show more You are interested in mechanisms of antibiotic resistance for your microbe of interest. The antibiotic you are studying is an inhibitor of the ribosome. A) Resistance mechanism: Multidrug efflux transporters act to pump toxic substances such as antibiotics out of the cell. These are usually ABC type transporters. Explain the advantage in using ABC transporters for this special function rather than using secondary transport systems that involve proton-motive force. Assume the toxins do not influence the proton-motive force or in any other way inhibit the secondary transport systems. B) Drug detection: Explain why the cell is more likely to employ a two-component system with a transmembrane sensor kinase (with sensor domain exposed to the periplasm) than a cytoplasmic one-component system to sense the antibiotic and induce expression of the efflux transporter. Show less

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